Blar i NTNU Open på forfatter "Hemler, Mary Elizabeth"
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Combined targeting of pathways regulating synaptic formation and autophagy attenuates Alzheimer’s disease pathology in mice
Bjorkli, Christiana; Hemler, Mary Elizabeth; Julian, Joshua B; Sandvig, Axel; Sandvig, Ioanna (Peer reviewed; Journal article, 2022)All drug trials completed to date have fallen short of meeting the clinical endpoint of significantly slowing cognitive decline in Alzheimer’s disease (AD) patients. In this study, we repurposed two FDA-approved drugs, ... -
In Vivo Microdialysis in Mice Captures Changes in Alzheimer´s Disease Cerebrospinal Fluid Biomarkers Consistent with Developing Pathology
Bjorkli, Christiana; Louet, Claire; Flo, Trude Helen; Hemler, Mary Elizabeth; Sandvig, Axel; Sandvig, Ioanna (Peer reviewed; Journal article, 2021)Background: Preclinical models of Alzheimer’s disease (AD) can provide valuable insights into the onset and progression of the disease, such as changes in concentrations of amyloid-β (Aβ) and tau in cerebrospinal fluid ... -
Risk for referral to the child welfare system following parental relationship transitions in Norway
Hemler, Mary Elizabeth; Kojan, Bente Heggem; Anthun, Kjartan Sarheim; Fauske, Halvor (Peer reviewed; Journal article, 2023)Background There is a lack of knowledge concerning how changes in family structures are associated with involvement in child welfare systems. Particularly little attention has been paid to the role of parental relationship ... -
Using microdialysis to administer and assess drugs aimed at attenuating Alzheimer’s disease-related neuropathology
Hemler, Mary Elizabeth (Master thesis, 2021)Alzheimer’s disease is the most common form of dementia and is characterized by the neuropathological hallmarks amyloid-β and neurofibrillary tangles. Despite tremendous efforts in understanding the molecular, pathophysiological, ...